The aim of the study is a scientific substantiation of the ways and mechanisms for the development of social responsibility of business in the regions of Kazakhstan in the context of the specifics and level of their socioeconomic development. Achieving this goal required solving a number of research tasks: identifying the stages of development of corporate social responsibility of business in Kazakhstan in the context of the specific development of the domestic business sector; consideration of the mechanism of interaction between business and government in solving the problems of regional economic systems; analysis of the practices of interaction between government, business and society on the example of domestic business structures.Methodology - When developing the research topic, the methods of system, comparative and statistical analysis, the method of expert assessments were used. The expert survey, the analysis of documents, the secondary analysis of sociological studies were used as empirical research methods.Conclusions - The domestic model of social responsibility has a significant political component, the main interaction in the field of CSR is carried out along the lines of «business power». Corporate social responsibility in Kazakhstan is based on informal and often non-transparent rules of interaction between the state and big business. At the same time, in the interaction of government and business, there is already a tendency towards institutionalization of relations, towards a transition from a policy of bargaining to a mutually beneficial partnership, for the time being mainly at the regional level. Understanding of social responsibility as a synonym for charity, which is often an informal social obligation for domestic business, is quite popular. In the area of CSR, each company is in search of its own balance between business interests, market challenges, public expectations and government requests.